ABSTRACT
Objective:To observe the effect of cognitive training based on PASS theory on cognition in patients with post-stroke cognitive impairment (PSCI). Methods:From August, 2018 to June, 2019, 42 patients with PSCI were randomly divided into control group (n = 21) and intervention group (n = 21). The intervention group accepted computer-assisted cognitive training based on the PASS theory, and the control group accepted routine computer-assisted cognitive training, for four weeks. They were assessed with Mini-Mental State Examination (MMSE) and Lowenstein Occupational Therapy Cognitive Assessment (LOTCA) before and after training. Results:There were 18 patients in each group finishing the trail. After training, the scores of MMSE and LOTCA increased in both groups (t > 8.831, P < 0.001), and increased more in the intervention group than in the control group (t > 2.198, P < 0.05). For the LOTCA factors scores, it increased in orientation, visual perception, spatial perception, motion praxis, visuomotor organization and thinking operations in both groups (t > 2.122, P < 0.05) after training, and increased more in the intervention group than in the control group in visual perception, spatial perception and thinking operations (t > 2.356, P < 0.05), and the differences of visuomotor organization was more in the intervention group than in the control group (t = 2.354, P < 0.05). Conclusion:Cognitive training based on PASS theory can improve cognition for patients with PSCI, especially for visual perception, spatial perception, thinking operations and visuomotor organization.
ABSTRACT
Aging leads to cognitive decline, including memory, attention, language and execution. Alzheimer's disease (AD) is a progressive neurodegenerative disorder closely related to age. Decreased cognitive function is one of its core symptoms. Transcranial direct current stimulation (tDCS) has been used in old healthy adults and AD patients to improve aging-related cognitive impairment. tDCS can improve memory (situational memory, semantic memory and working memory), language, error awareness and attentional functions in the old adults, which were influenced by many factors, such as education levels, stimulation parameters and individual task baseline scores, etc. For AD patients, tDCS may improve their cognitive function, which is influenced by the factors as anatomical differences, severity of disease, stimulation parameters and assessment tools, etc. Cognitive training combined with tDCS can further improve cognitive function in old adults and AD patients.